Antiseptics and disinfectants
Natthasit Tansakul
Vet.Pharm.KU.
Learning strategies and objectives
Sit in lecture-class > 80%
Prepare hand out (Word document and PPT)
Allow you asking both in/off class
Discussion and interactive verbal are permitted
Evaluation Examination (……%; Fill in blank, Multiple choices)
Antiseptics and disinfectants
Sterilization
    - Destroy microbials /may including spores
    - Boiling, Oven, Autoclave
Disinfectant:
Antiseptic: Topical (mucous, tissues), Spores?
Disinfectant: Using on floor, instruments
Action depending
Chemical properties
Concentration
Duration
Sensitivity of microbials
Kind of microbials: Bacteria (+/-),Viral
Environment: pH, Temp, matter
Ideal disinfectants
Destroy all kind of microbial
Rapidly action
Long duration of action
High stability
Less or no toxic and adverse effect
Cheap and easy to use
Disinfectants (Chemical properties)
Alcohol
Aldehyde
Halogens
Heavy metal
Oxidizing agents
Phenol
Surface active agents
Acids
Nitrofurazone
Ethylene oxide
Miscellaneous
Disinfectant (Mode of action)
Denature protein and lipid:
QACs
Acids/ Basic
Alcohols
Phenolics
Biguanides
Release chemical bond: Aldehydes,Enzymes
Increase positive ion (Oxidant): Halogens, H2O2, Ozone
Antiseptic agents
Alcohols
Chlorhexidine
Oxidizing agents
        : Iodine, Iodophors
            : Peroxides
            - Hydrogen peroxide                                - Potassium permanganate